Alpha Lipoic Acid Supplement Review

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Alpha Lipoic Acid
  Evaluated for:
Effectiveness Rating Effectiveness Rating
Peripheral Neuropathy
+3 (Strong Evidence)
Diabetes Type 2
+2 (Moderate Evidence)


  • Pain, numbness, pins-and-needles sensations, and burning associated with diabetic peripheral neuropathy can all improve with alpha-lipoic acid.
  • Blood sugars and insulin sensitivity have also been shown to improve with alpha-lipoic acid therapy.
  • Compared to current medical therapies that have a significant incidence of side effects, alpha-lipoic acid has few side effects and is generally very well tolerated.
  • Alpha-lipoic acid may have other important benefits. Combined with acetyl L-carnitine, it has been shown to help memory retention in animals, but large scale human studies have not been conducted.
  • Alpha-lipoic acid has an excellent safety profile and experts generally believe it is safe for use at recommended doses for up to 2 years.


  • It can take up to 3-5 weeks to experience the benefits of this therapy.
  • Although oral preparations have also been shown to be effective, the alpha-lipoic acid preparations used in the clinical trials we studied were delivered primarily by intravenous route. This is not practical for widespread use.
  • Side effects, while rare, consist of gastrointestinal upset, dizziness and rashes.
  • There aren’t a lot of cons to using this product.

If you take diabetes medication, alpha-lipoic acid can lower your sugar levels too rapidly. Because of this, you will need to check with your doctor. He or she may want to decrease the doses of some or all of your diabetes medicines before you begin taking this supplement.

DOSAGE: The dosage range is between 600 and 1200 mg per day. Our suggestion is to begin taking alpha lipoic acid at 300 mg three times a day, and to work with your doctor on dose adjustment.

CONCLUSION: We conclude that alpha-lipoic acid is a safe and effective supplement for improving diabetic peripheral neuropathy. It is an excellent alternative treatment to other medications for diabetic peripheral neuropathy, and its use is well supported in many clinical studies. If you use it, remember to include it in your list of medications when you visit your doctor and other health care providers.

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