CoQ10 Supplement Review

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CoQ10
  Evaluated for:
Effectiveness Rating Effectiveness Rating
High blood pressure (hypertension)
+3 (Strong Evidence)
Statin-induced side effects associated with low CoQ10 levels
0 (Effectiveness Unclear)

PRO

  • CoQ10 “relaxes” blood vessels, playing a beneficial role in the treatment of high blood pressure. Some patients may be able to decrease the dosage or even discontinue their high blood pressure medications altogether while taking CoQ10 (after consultation with a physician).
  • “Statin” medications can lower body levels of CoQ10, an important antioxidant involved in cellular energy production. Though we don’t yet know the benefits, supplemental CoQ10 can restore these levels in the body.

CON

  • Only about 50% of people who take CoQ10 will experience an improvement in blood pressure, and it can take up to four to eight weeks to occur.
  • The side effects associated with CoQ10 are mostly gastrointestinal, such as stomach upset, nausea, and diarrhea. It may also cause a skin rash in some people.
  • Replacing the CoQ10 lost while taking a “statin” cholesterol lowering medicine is without proven benefit.

* *ADVISORY* *
CoQ10 may lower blood sugar levels, and it should be monitored in patients with diabetes or patients taking medications or supplements that are known to lower blood sugar.
Blood pressure must be monitored with the use of CoQ10.
Caution is advised in people who have bleeding disorders or who are taking drugs that increase risk of bleeding, such as aspirin. For example, patients on CoQ10 are usually asked to discontinue use one week prior to surgery.
There may be a drug interaction between CoQ10 and Warfarin (Coumadin) that reduces the effects of Warfarin.
For this and many other reasons, patients need to discuss the use of CoQ10 with their medical provider.

DOSAGE:For the treatment of high blood pressure, take 100 mg of CoQ10 twice a day. For statin induced low CoQ10 levels, take 100 to 200 mg once daily.

CONCLUSION:We conclude that CoQ10 is a safe and effective product for the treatment of high blood pressure. While it shows promise for treating low CoQ10 levels associated with the use of statin medications, there is not enough evidence for us to recommend this indicated use. Remember to include it in your list of medications when you visit your doctor and other health care providers.

REFERENCES
“CoQ10.” ConsumerLab.com. ConsumerLab.com LLC, 2013. 13 June 2013.
“Coenzyme Q10.” Natural Standard –The Authority on Integrative Medicine. Natural Standard, 2013.
“Coenzyme Q-10.” Natural Medicines Comprehensive Database. Therapeutic Research Faculty, 2013. 8 November 2013.
Suzuki, T. et al. Atrovastatin-Induced Changes in Plasma Coenzyme Q10 and Brain Natriuretic Peptide in Patients With Coronary Artery Disease. Int Heart J (2008) 49, 423-433
Hershey, A.D. et al. Coenzyme Q10 Deficiency and Response to Supplementation in Pediatric and Adolescent Migraine. Headache (2007) 47:73-80
Adarsh, K. et al. Coenzyme Q10 (CoQ10) in isolated diastolic heart failure in hypertropic cardiomyopathy (HCM). BioFactors (2008) 32, 145-149
Schaars, C.F., Stalenhoef, A.F.H. et al. Effects of ubiquinone (coenzyme Q10) on myopathy in statin users. Current Opinion in Lipidology (2008) 19:553-557
Langsjoen, P.H., Langsjoen, A.M. et al. Supplemental ubiquinol in patients with advanced congestive heart failure. BioFactors (2008) 32, 119-128
Schmelzer, C. et al. Functions of coenzyme Q10 in inflammation and gene expression. BioFactors (2008) 32, 179-183
Wyman, M. et al. Coenzyme Q10: A therapy for hypertension and statin-induced myalgia? Cleveland Clinic Journal of Medicine (2010) 77, 435-442
Hidaka, T. et al. Safety assessment of coenzyme Q10 (CoQ10). BioFactors (2008) 32, 199-208
Molyneux, S.L. et al. Coenzyme Q10, An Independent Predictor of Mortality in Chronic Heart Failure. JACC (2008) 52, 1435-1441
Sandor, P.S. et al. Efficacy of conenzyme Q10 in migraine prophylaxis: A randomized controlled trial. Neurology (2005) 64:713-715
Kalenikova, E.I. et al. Pharmacokinetics of Coenzyme Q10. Byulleten’ Eksperimental’noi Biologii i Meditsiny (2008) 146, 288-291


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