* *ADVISORY* *Grape seed’s safety record in pregnant and nursing women is unknown, so you should avoid grape seed if you are pregnant or nursing. You should avoid grape seed if you have a bleeding disorder or take coumadin, aspirin, NSAIDS because it may increase the risk of bleeding. Grape seed should be discontinued two weeks prior to any planned surgery, whether dental or otherwise. Please do not consider taking it if you are allergic to grapes, because, like the grapes from which it is derived, it has the potential to cause a severe allergic reaction.
DOSAGE:For chronic venous insufficiency (leg swelling or hemorrhoids), take grape seed extract in a dose of 150-300 mg per day.
CONCLUSION:We conclude that grape seed extract is a safe and effective product for chronic venous insufficiency, or swollen legs or hemorrhoids due to lack of tone in the veins. It may also help reduce leg swelling after surgery or injury, but this requires further study. It is well tolerated, and the downside is relatively minimal.