Grape Seed Extract Supplement Review

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Grape Seed Extract
  Evaluated for:
Effectiveness Rating Effectiveness Rating
Chronic venous insufficiency
+3 (Strong Evidence)
Weight Loss
0 (Effectiveness Unclear)


  • Grape seed extract comes from the fruits, leaves, sap and root of grape vines. It has been used medicinally since ancient times. They contain a class of compounds called proanthocyanidins, or flavonols. They are beneficial to health, and contribute the red color to grapes, cranberries, black currants, green and black teas, and many herbs and vegetables.
  • Grape seed is effective in treating chronic venous insufficiency (leg swelling), and hemorrhoids, both of which are caused by decreased strength and tone in vein walls.
  • Grape seed may reduce leg swelling following surgery or sports injuries. While this indication needs further study, there is a possibility that it may help.
  • Grape seeds are generally recognized as safe.
  • It is possible that some indirect weight loss occurs due to the loss of fluid from the legs, but this is merely a fortunate side effect. There is no beneficial evidence for the weight loss itself.


  • Grape seed may increase the risk of bleeding in patients on blood thinner medicines like coumadin or aspirin. It may also increase the risk of bleeding in patients with bleeding disorders.
  • We could not find good research to support the direct use of grape seeds for weight loss. Future studies are needed.
  • Side effects may include dizziness, nausea and vomiting, hives, headache, high blood pressure, indigestion, increased bleeding risk.

Grape seed’s safety record in pregnant and nursing women is unknown, so you should avoid grape seed if you are pregnant or nursing. You should avoid grape seed if you have a bleeding disorder or take coumadin, aspirin, NSAIDS because it may increase the risk of bleeding. Grape seed should be discontinued two weeks prior to any planned surgery, whether dental or otherwise. Please do not consider taking it if you are allergic to grapes, because, like the grapes from which it is derived, it has the potential to cause a severe allergic reaction.

DOSAGE:For chronic venous insufficiency (leg swelling or hemorrhoids), take grape seed extract in a dose of 150-300 mg per day.

CONCLUSION:We conclude that grape seed extract is a safe and effective product for chronic venous insufficiency, or swollen legs or hemorrhoids due to lack of tone in the veins. It may also help reduce leg swelling after surgery or injury, but this requires further study. It is well tolerated, and the downside is relatively minimal.

“Grape Seed.” Natural Standard –The Authority on Integrative Medicine. Natural Standard, 2013.
“Grape.” Natural Medicines Comprehensive Database. Therapeutic Research Faculty, 2013. 8 November 2013.
Vogels, N. et al. The effect of grape-seed extract on 24 h energy intake in humans. European Journal of Clinical Nutrition (2004) 58, 667-673
Pajuelo, D. et al. Acute Administration of Grape Seed Proanthocyanidin Extract Modulates Energetic Metabolism in Skeletal Muscle and BAT Mitochondria. Journal of Agricultural and Food Chemistry (2011) 59, 4279-4287

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