Hyaluronic Acid Supplement Review

Meet Our Experts
Cleveland Clinic, ranked as one of the nation’s best hospitals overall (4th in the country) by U.S. News & World Report 2013-14, is proud to offer expert advice and guidance to help you on your journey to wellness.
Meet Our Experts
Hyaluronic Acid
  Evaluated for:
Effectiveness Rating Effectiveness Rating
Aging skin
0 (Evidence Unclear)
Dry eyes
0 (Evidence Unclear)
Knee pain
0 (Evidence Unclear)


  • Hyaluronic acid is a long elastic molecule that binds water, and so lubricates tissues and joints. It serves as a component of connective tissues throughout the body.
  • It has been used to treat a variety of problems, including arthritis, dry eyes, and aging skin. It can be injected (directly into joints or skin), taken orally, or applied topically to skin.
  • Treating skin with hyaluronic acid is thought to decrease wrinkles and to improve its general appearance. It may also aid in skin healing.


  • Many commercially available sources of hyaluronic acid are prepared from bird protein that is derived either from the comb of chickens or from an extract made from sternal cartilage. Therefore, individuals with allergy or sensitivity to eggs or feathers should not use these products.
  • Hyaluronic acid may increase the risk of bleeding when taken orally.

Individuals with allergy or sensitivity to eggs should not use hyaluronic acid. If you take medications that affect blood clotting, such as warfarin (coumadin) or aspirin, hyaluronic acid may increase your risk of bleeding. If you are take any blood thinning medications, we recommend discussing this with your medical provider before you consider taking any of these supplements.

DOSAGE:In adults over age 18, 50 milligrams of hyaluronic acid have been taken by mouth 1-2 times daily with meals. Osteoarthritis has been treated with 80 mg of a chicken comb extract (containing 60-70% hyaluronic acid) taken daily for eight weeks, and with 20 mg hyaluronic acid injected directly into the knee joint once a week for three weeks. Dry eye has been treated with hyaluronic acid 0.2% eye drops 3-4 times daily for 3 months.

CONCLUSION:We conclude that while hyaluronic acid shows promise for treating aging skin, knee pain, and dry eyes, there is not enough evidence for us to support its use orally. If you do elect to try it, discuss your decision with your doctor, and observe carefully for any changes to your health.

“Hyaluronic Acid.” Natural Standard –The Authority on Integrative Medicine. Natural Standard, 2013.
“Hyaluronic Acid.” Natural Medicines Comprehensive Database. Therapeutic Research Faculty, 2013. 8 November 2013.
Schwartz, S., Park, J. et al. Ingestion of BioCell Collagen®, a novel hydrolyzed chicken sternal cartilage extract; enhanced blood microcirculation and reduced facial aging signs. Clinical Interventions in Aging (2012) 7, 267-273
Rah, M. et al. A review of hyaluronan and its ophthalmic applications. Optometry (2011) 82, 38-43
Schauss, A. et al. Effect of the Novel Low Molecular Weight Hydrolyzed Chicken Sternal Cartilage Extract, BioCell Collagen, on Improving Osteoarthritis-Related Symptoms: A Randomized, Double-Blind, Placebo-Controlled Trial. Journal of Agricultural and Food Chemistry (2012) 60, 4096-4101
McCann, L. et al. Effectiveness of Artificial Tears in the Management of Evaporative Dry Eye. Cornea (2012) 31(1): 1-5
Prabhasawat, P. et al. Performance profile of sodium hyaluronate in patients with lipid tear deficiency: randomised, double-blind, controlled, exploratory study. Br J Ophthalmol (2007) 91: 47-50
Draelos, Z.D. et al. New treatments for restoring impaired epidermal barrier permeability: Skin barrier repair creams. Clinics in Dermatology (2012) 30, 345-348

Untitled Document
Get Your Daily Tip
Start living healthier with our FREE daily wellness tips!
Wellness Experts
Our team of Cleveland Clinic Wellness experts is here to show you how the mind, body and food work together to help you live healthier, feel better and prevent or even reverse disease.

Meet Our Experts