Ossein Hydroxyapatite Supplement Review

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Ossein Hydroxyapatite
  Evaluated for:
Effectiveness Rating Effectiveness Rating
Supplementation (addition) to calcium to prevent osteoporosis
0 (Effectiveness Unclear)


  • Many studies support supplementation with ossein hydroxyapatite. It appears to improve bone retention (compared to calcium carbonate) by about 1%. While this may not seem like much, it may be enough to keep you from breaking a bone.
  • Theoretically, ossein hydroxyapatite, which is derived from cow bone, should improve bone strength.
  • Medications used to treat osteoporosis increase bone density by several percentage points over several years. So even small differences in bone density do change clinical outcomes for the better.
  • Constipation, the most common side effect seen with calcium supplementation (15%), seems to be much lower with ossein hydroxyapatite (4%).


  • Ossein hydroxyapatite should be considered an addition to, and not a replacement for, current osteoporosis therapies.
  • Ossein hydroxyapatite has been studied with calcium carbonate only, and not with calcium citrate, which probably has better bone preserving effects. However, calcium citrate is more costly and more complicated because you have to take more capsules per day to get the same amount of calcium.
  • Cow bones may carry the protein for mad cow disease.
  • The real goal of any osteoporosis treatment is to prevent fractures. We really don’t know if ossein hydroxyapatite produces this outcome because such a study would be costly and it’s unlikely that one would be conducted soon.

Ossein hydroxyapatite should not be considered a replacement for standard osteoporosis management and treatment.

DOSAGE:The studies we reviewed tested dosages from 3.2 to 6.4 grams per day of ossein hydroxyapatite, so these are the doses we recommend. We also recommend taking additional calcium in the form of a supplement or dietary source to reach 1800 mg per day suggested for postmenopausal women to prevent osteoporosis.

CONCLUSION:We conclude that while ossein hydroxyapatite appears promising as an addition to calcium supplementation in women who do not have osteoporosis, there is not enough support for its use. It appears to have a greater impact on bone mineral density than calcium carbonate. It does contain some calcium (although less than plain calcium carbonate), but it is more expensive. More trials are needed to see if this supplement results in fewer fractures. If you do elect to try it, remember to include it in your list of medications when you visit your doctor and other health care providers.

“Calcium.” Natural Standard –The Authority on Integrative Medicine. Natural Standard, 2013.
Castelo-Branco, C. et al. Efficacy of ossein-hydroxyapatite complex compared with calcium carbonate to prevent bone loss: a meta-analysis. Menopause: The Journal of The North American Menopause Society (2009) 16(5):984-991
Fernandez-Pareja, A. et al. Prevention of Osteoporosis: Four-Year Follow-Up of a Cohort of Postmenopausal Women Treated with an Ossein-Hydroxyapatite Compound. Clin Drug Invest (2007) 4:227-232

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