Passion Flower Supplement Review

Meet Our Experts
Cleveland Clinic, ranked as one of the nation’s best hospitals overall (4th in the country) by U.S. News & World Report 2013-14, is proud to offer expert advice and guidance to help you on your journey to wellness.
Meet Our Experts
Passion Flower
  Evaluated for:
Effectiveness Rating Effectiveness Rating
0 (Effectiveness Unclear)
0 (Effectiveness Unclear)
0 (Effectiveness Unclear)
Motor function
0 (Effectiveness Unclear)


  • Passion flower comes from the above-ground parts of the plant Passiflora incarnata. It is used to help people sleep, to treat anxiety and to improve motor function and memory.
  • Passion flower has been compared to the benzodiazepine oxazepam and may ease anxiety without impairing memory or motor skills.
  • Passion flower is an alternative to benzodiazapine medications for treating anxiety disorders.
  • Passion flower is generally safe.


  • Side effects of passion flower may include dizziness, confusion, and sleepiness.
  • Passion flower may have a synergistic effect, causing a possibly unsafe level of sedation for those already taking medication to help with insomnia.
  • Patients on blood-pressure-lowering medication may experience dizziness due to excessive blood pressure lowering if they add passion flower to their supplement regimen.
  • While there is some evidence that passion flower liquid extracts can be taken orally safely for up to one month, insufficient information is available to draw conclusions on the safety of topical use of passion flower.
  • We need more good studies to determine the effectiveness of passion flower for treating anxiety.

Passion flower contains a component called coumarin that may increase the risk of bleeding. It should not be taken in pregnancy or by individuals on coumadin or sedating drugs.

DOSAGE:Take 45 drops of liquid extract for generalized anxiety. For sleep, take a 90 mg tablet or as a tea at bedtime.

CONCLUSION:We conclude that while passion flower shows promise for treating sleep disorders, anxiety, memory and motor function, there is not enough evidence for us to recommend its use for this indication. If you do elect to try it, please discuss its use with your doctor, and observe carefully for any changes in your health.

“Passion Flower.” Natural Standard –The Authority on Integrative Medicine. Natural Standard, 2013.
“Passionflower.” Natural Medicines Comprehensive Database. Therapeutic Research Faculty, 2013. 8 November 2013.
Lakhan, S. et al. Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review. Nutrition Journal (2010) 9:42
Kinrys, G. et al. Natural Remedies for anxiety disorders: potential use and clinical applications. Depression and Anxiety (2009) 26:259-265

Untitled Document
Get Your Daily Tip
Start living healthier with our FREE daily wellness tips!
Wellness Experts
Our team of Cleveland Clinic Wellness experts is here to show you how the mind, body and food work together to help you live healthier, feel better and prevent or even reverse disease.

Meet Our Experts