* *ADVISORY* *Rhodiola inhibits a specific metabolic pathway in the liver called CYP3A4. Many drugs are metabolized by this pathway. Use of rhodiola at the same time as other drugs metabolized by CYP3A4 may alter blood concentrations and increase the risk of adverse effects.
DOSAGE: Doses of 100-400mg of Rhodiola rosea taken once daily on an empty stomach have been studied for clinical effectiveness. Start with the lowest dose, and increase by 100 mg weekly, up to 400 mg total daily dose. Some practitioners recommend taking it early in the day to reduce the risk of insomnia, and scheduling a drug holiday (discontinuation) every 1-2 weeks. Use a standardized extract containing 2-3% rosavin and 0.8-1% salidroside.
CONCLUSION: If you elect to try Rhodiola, remember to include it in your list of medications when you visit your doctor and other health care providers.