SAM-e Supplement Review

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  Evaluated for:
Effectiveness Rating Effectiveness Rating
+2 (Moderate Evidence)
+2 (Moderate Evidence)


  • SAM-e appears to be as effective as some of the prescription medications for treating depression.
  • It seems to have fewer side effects, and the treatment benefit appears sooner.
  • SAM-e can be used in combination with prescription antidepressants, and it can improve their effect in people whose depression does not respond sufficiently to standard treatment with typical appropriate antidepressant therapy.
  • SAM-e appears to be as beneficial for treating osteoarthritis as some non-steroidal (NSAID’s) anti-inflammatory medications (like ibuprofen and naproxen).
  • SAM-e has fewer potential side effects than NSAID’s.


  • SAM-e is more expensive than many of the conventional therapies used to treat depression and osteoarthritis. This consideration is of particular importance given its potential for long-term use.
  • Otherwise, there are not a lot of cons associated with this product.

Due to the serious nature of depression, people should use SAM-e only with the knowledge and under the guidance of their mental health specialist/provider.

DOSAGE:For depression, take 400 mg three to four times daily.
For osteoarthritis, take 400 mg two to three times a day.

CONCLUSION:We conclude that SAM-e is a safe and effective product for the treatment of depression and osteoarthritis. If you elect to try it, remember to include it in your list of medications when you visit your doctor and other health care providers.

“SAMe.” LLC, 2013. 3 November 2011.
“SAM-e.” Natural Standard –The Authority on Integrative Medicine. Natural Standard, 2013.
“SAMe.” Natural Medicines Comprehensive Database. Therapeutic Research Faculty, 2013. 8 November 2013.
Williams, A. et al. S-Adenosylmethionine (SAMe) as Treatment for Depression: A Systematic Review. Clinical and Investigative Medicine (2005) 28(3):132-139
Najm, W. et al. S-Adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: A double-blind cross-over trial. BMC Musculoskeletal Disorders (2004), 5:6

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