Sulforaphane

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Sulforaphane
  Evaluated for:
Effectiveness Rating Effectiveness Rating
Reduction of Helicobacter pylori colonization
+1 (Slight Evidence)
Cancer risk reduction
0 (Unclear Effectiveness)

PRO

  • Sulforaphane is found in broccoli and broccoli sprouts, defined as broccoli plants that are 3-4 days old.
  • Absorption of sulforaphane was more effective from raw than cooked broccoli and broccoli sprouts. It is unclear whether frozen broccoli/broccoli sprouts provide the same benefit. Because sulforaphane is destroyed by heat, broccoli sprouts must be eaten raw in order to ingest adequate amounts.
  • The optimal dose and duration of use of sulforaphane for treating Helicobacter pylori infection is unclear, but clinical trials showed that ingestion of 70 grams of broccoli sprouts once daily for 8 weeks was successful.
  • Side effects with sulforaphane are minimal, and it is generally well tolerated.
  • Though the likelihood of drug interactions is minimal, certain drugs, herbs, or supplements processed through the cytochrome P450 system may interact with sulforaphane, leading to increase in drug levels. Pharmacists and physicians will be able to investigate whether any medication you take is processed by the P450 system.

CON

  • Eating ½ cup broccoli sprouts 2-3 times weekly has been suggested to reduce cancer risk, but the human data on this benefit are very limited.
  • The effect of sulforaphane on Helicobactor pylori infection lasted only as long as the sulforaphane was being taken. Once the supplement was stopped, the infection returned.
  • Even though the studies of sulforaphane for cancer risk reduction and Helicobactor pylori treatment are encouraging, the studies are limited in size and number. More studies are needed before making definitive recommendations.
  • Because sulforaphane is metabolized by the cytochrome P450 system of enzymes in the liver, it may affect metabolism of other medications. Check with your physician before you decide to take it.

DOSAGE: The research results are insufficient to offer definitive doses for treatment.

CONCLUSION: If you elect to try Sulforaphane, remember to include it in your list of medications when you visit your doctor and other health care providers.


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