Pantothenic Acid (Vitamin B5) Supplement Review

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Pantothenic Acid (Vitamin B5)
  Evaluated for:
Effectiveness Rating Effectiveness Rating
Vitamin B5 deficiency (documented)
+3 (Strong Evidence)
0 (Effectiveness Unclear)
Wound healing
0 (Effectiveness Unclear)
LDL cholesterol lowering
0 (Effectiveness Unclear)
0 (Effectiveness Unclear)
Adrenal fatigue
0 (Effectiveness Unclear)
0 (Effectiveness Unclear)


  • One of many B vitamins, pantothenic acid is essential for metabolism of carbohydrates, proteins, and fats, as well as for synthesis of hormones and cholesterol.
  • Good dietary sources include meats, liver, kidney, fish, shellfish, chicken, vegetables, legumes, eggs, and milk. Freezing or canning may reduce content.
  • Pantothenic acid is included in daily multivitamins and vitamin B complex supplements.
  • Pantothenic acid in food and supplements appears safe, with few if any serious side effects.
  • Patients at high risk for malnutrition may benefit from a pantothenic acid supplement.


  • Because pantothenic acid is widely distributed in plants and animals up and down the food chain, an isolated deficiency is rare.
  • Besides being common in the food supply, it is is also found in most multivitamins. Further supplementation, therefore, is usually unnecessary.
  • To this end, additional unrecognized sources, such as vitamin waters and other vitamin-supplemented foods and drinks, could result in inadvertent ingestion of toxic amounts of certain B vitamins. This is especially true of vitamins B6 (pyridoxal) and B9 (folic acid).

Pantothenic acid supplementation may affect other medications, especially blood thinners (coumadin) and medicines used to treat Alzheimer's dementia. If you take medications that affect blood clotting, we recommend speaking with your medical provider before taking these supplements.

DOSAGE:The daily recommended dose ranges between 5 to 10 mg per day.

CONCLUSION:We conclude that Vitamin B5 (pantothenic acid) is a safe and effective product for the treatment of a documented vitamin B5 deficiency. Because Vitamin B5 is so common in the food supply, we recommend getting your B5 through whole food sources. It may have potential benefits to osteoarthritis, wound healing, LDL cholesterol lowering, acne, adrenal fatigue, or dermatitis. If you do elect to try it, please discuss your decision with your doctor, and observe carefully for any changes in your health.

“Pantothenic Acid.” Natural Standard –The Authority on Integrative Medicine. Natural Standard, 2013.
“Pantothenic Acid (Vitamin B5).” Natural Medicines Comprehensive Database. Therapeutic Research Faculty, 2013. 8 November 2013.
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Udompataikul, M. et al. Comparative Trial of 5% Dexpanthenol in Water-in-Oil Formulation With 1% Hydrocortisone Ointment in the Treatment of Childhood Atropic Dermatitis: A pilot Study. Journal of Drugs in Dermatology (2012) 11(3):366-374

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