Vitamin D3 Supplement Review

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Vitamin D3
  Evaluated for:
Effectiveness Rating Effectiveness Rating
Prevention and treatment of osteoporosis
+3 (Strong Evidence)
Rickets
+3 (Strong Evidence)
Vitamin D deficiency
+3 (Strong Evidence)
Prevention of multiple sclerosis
0 (Effectiveness Unclear)
Lupus
0 (Effectiveness Unclear)
Coronary heart disease
0 (Effectiveness Unclear)
Various cancers
0 (Effectiveness Unclear)
Other conditions which have been associated with vitamin D deficiency
0 (Effectiveness Unclear)

PRO

  • Many of these conditions are quite serious. Given that the risk, expense, and side effects of vitamin D3 supplementation are very low, treatment is safe and easy.
  • Given the low cost and low risk of side effects, it seems prudent to take supplemental vitamin D3.
  • Vitamin D levels can be measured, so your doctor can determine exactly how much you need, and then make a recommendation based on the results.

CON

  • Vitamin D3 doesn’t work well when taken alone. It needs to be given in combination with calcium in order to prevent and treat osteoporosis. Even so, the benefit is small.
  • Vitamin D3 supplementation does not always produce reliable clinical improvement or reduce the risk of developing these conditions.
  • Commercially available vitamin D3 preparations do not always contain the actual amount advertised on the label.

* *ADVISORY* *
Too much vitamin D3 can cause serious toxicity, which can, in rare cases, be life threatening. Ask your medical provider to check your levels. This will help to determine your correct dose.

DOSAGE:Check with your medical provider to help determine your ideal dosage. For everyone over one year of age, a dosage of 2000 IU (50 mcg) daily should not be exceeded.

CONCLUSION:We conclude that vitamin D3 is a safe and effective product for the treatment and prevention of osteoporosis, rickets and vitamin D deficiency. There is not enough evidence to support its use for the other conditions listed above. If you do elect to try it, tell your health care providers. A healthy diet with adequate calcium, Vitamin D, sunshine, and physical activity will help achieve strong bones and may reduce your risk of osteoporosis. Go for a walk outside, or take a winter vacation to a sunny spot!

REFERENCES
“Vitamin D.” ConsumerLab.com. ConsumerLab.com LLC, 2013. 4 October 2013.
“Vitamin D3.” Natural Standard –The Authority on Integrative Medicine. Natural Standard, 2013.
“Vitamin D.”Natural Medicines Comprehensive Database. Therapeutic Research Faculty, 2013. 8 November 2013.
Giovannucci, E. et al. 25-Hydroxyvitamin D and Risk of Myocardial Infarction in Men: A Prospective Study. Arch Intern Med (2008) 168(11):1174-1180
Binkley, N. et al. 25-Hydroxyvitamin D Measurement, 2009: A Review for Clinicians. Journal of Clinical Densitometry: Assessment of Skeletal Health (2009) 12(4):417-427
Lu, Z. et al. An evaluation of the vitamin D3 content in fish: Is the vitamin D content adequate to satisfy the dietary requirement for vitamin D?. Journal of Steroid Biochemistry & Molecular Biology (2007) 103, 642-644
Suzuki, Y. et al. Anti-inflammatory effect of 1a,25-dihydroxyvitamin D3 in human coronary arterial endothelial cells: Implication for the treatment of Kawasaki disease. Journal of Steroid Biochemistry & Molecular Biology (2009) 113, 134-138
Parekh, N. et al. Association Between Vitamin D and Age-Related Macular Degeneration in the Third National Health and Nutrition Examination Survey, 1988 Through 1994. Arch Ophthalmol (2007) 125:661-669
Dobnig, H. et al. Independent Association of Low Serum 25-Hydroxyvitamin D and 1, 25-Dihydroxyvitamin D Levels With All-Cause and Cardiovascular Mortality. Arch Intern Med (2008) 168(12):1340-1349
Patient level pooled analysis of 68500 patients from seven major vitamin D fracture trials in US and Europe. BMJ (2010) 340:b5463
Kim, D.H. et al. Prevalence of Hypovitaminosis D in Cardiovascular Diseases (from the National Health and Nutrition Examination Survey 2001 to 2004). The American Journal of Cardiology (2008) 102:1540-1544
Wagner, C. et al. Prevention of Rickets and Vitamin D Deficiency in Infants, Children, and Adolescents. Pediatrics (2008) 122:1142-1152
Michos, E. et al. Serum 25-Hydroxyvitamin D Levels Are Not Associated with Subclinical Vascular Disease or C-Reactive Protein in the Old Order Amish. Calcif Tissue Int (2009) 84:195-202
Pittas, A. et al. Systematic Review: Vitamin D and Cardiometabolic Outcomes. Annals of Internal Medicine (2010) 152:307-314
Wei, M., Giovannucci, E. et al. Vitamin D and multiple health outcomes in the Harvard cohorts. Mol Nutr Food Res (2010) 54, 1114-1126
Arad, Y. et al. Serum concentration of calcium, 1,25 vitamin D and parathyroid hormone are not correlated with coronary calcifications. An electron beam computed tomography study. Coronary Artery Disease (1998) 9:513-518
Lee, J.H. et al. Vitamin D Deficiency: An Important, Common, and Easily Treatable Cardiovascular Risk Factor?. Journal of the American College of Cardiology (2008) 52:1949-56
Freedman, B. et al. Vitamin D, Adiposity, and Calcified Atherosclerotic Plaque in African-Americans. J Clin Endocrinol Metab (2010) 95:1076-1083


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