Glutamine Supplement Review

Meet Our Experts
Cleveland Clinic, ranked as one of the nation’s best hospitals overall (4th in the country) by U.S. News & World Report 2013-14, is proud to offer expert advice and guidance to help you on your journey to wellness.
Meet Our Experts
  Evaluated for:
Effectiveness Rating Effectiveness Rating
Lowered immunity
+2 (Moderate Evidence)
+2 (Moderate Evidence)
Mouth inflammation
+2 (Moderate Evidence)
Muscle Health
+2 (Moderate Evidence)


  • Glutamine, an amino acid manufactured in the body and found in high-protein foods such as meat, fish, beans, and dairy, is used to strengthen the immune system, to help treat diarrhea by improving protein balance in the intestinal tract, and to provide nutrition to your muscles. During times of physical stress and trauma, the body consumes more glutamine than it can produce, and glutamine becomes depleted.
  • There is good evidence for the use of glutamine in patients to decrease diarrhea and inflammation of the lining of the mouth.
  • Glutamine is safe to try for patients with inflammatory bowel disease, diarrheal illnesses and inflammation of the lining of the mouth.


  • No evidence exists for the use of glutamine for Crohn’s disease, ADHD, or to enhance muscle development in body builders.
  • One report suggested that glutamine triggered mania in two patients not known to be bipolar.
  • Glutamine can cause Chinese restaurant syndrome, a sensation of burning, numbness, tingling, nausea or weakness, especially in those individuals who are sensitive to MSG.

Glutamine should be used with caution in patients with renal failure and liver disease, because it can increase liver function tests and increase serum ammonia levels. Glutamine may interfere with the metabolism of most anti-seizure medications, causing break-through seizures.

DOSAGE:Glutamine powder is commonly used in dosages of 5 to 10 gm (and up to a maximum of 14 gm) daily.

CONCLUSION:We conclude that glutamine is a safe and effective product for treating stress-related immunodeficiency, diarrhea, mouth inflammation, and overall muscle health. It should be used with caution in patients with liver failure. High-protein foods such as meat, fish, beans, and dairy products are excellent sources of glutamine. Typical daily intake from food ranges from approximately 1 to 6 g. If you elect to try it, remember to include it in your list of medications when you visit your doctor and other health care providers.

“Glutamine.” LLC, 2013. 15 May 2013
“Glutamine.” Natural Standard –The Authority on Integrative Medicine. Natural Standard, 2013.
“Glutamine.” Natural Medicines Comprehensive Database. Therapeutic Research Faculty, 2013. 8 November 2013.
Amasheh, M. et al. Barrier Effects of Nutritional Factors. New York Academy of Sciences (2009)1165: 267-273
Glutamine. EBSCO Publishing (2011) 1-7
L-Glutamine. Alternative Medicine Review (2001) 6(4): 406-410

Untitled Document
Get Your Daily Tip
Start living healthier with our FREE daily wellness tips!