Niacinamide Supplement Review

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  Evaluated for:
Effectiveness Rating Effectiveness Rating
Age-related skin changes (including wrinkling and discoloration)
+3 (Strong Evidence)


  • Niacinamide (or niacin) is a form of Vitamin B3 with antioxidant properties. It affects genes that cause inflammation and cell damage and is used as an ingredient in cosmetic creams to improve skin appearance.
  • Niacin prevents water loss in skin, increasing its hydration and elasticity. One study showed it to be more effective than petrolatum (petroleum jelly).
  • Niacin improves the appearance of wrinkles and decreases discoloration, redness and sallow appearance. How refreshing!
  • Niacin calms down skin inflammation and can increase collagen production in the skin.
  • Niacinamide gel (4%) improves acne as much as the prescription strength medication clindamycin.
  • Niacin is well tolerated and nonirritating to the skin.
  • Topical niacin improves wrinkles faster and with fewer side effects than tretinoin (retinoic acid).
  • This is the one vitamin with solid evidence to show that it decreases the changes associated with aging and inflammation long-term, and improves your appearance short-term.


  • It may take up to 4 to 8 weeks before you notice the benefits of this therapy.
  • The concentration of niacinamide is not always indicated on product labels, so it may be hard to determine the actual dose you are using.
  • You may see a slight increase in redness for the first two weeks or so.


DOSAGE:Dosing in topical preparations ranges from .0001% to 3%, but it is not always found on the product label. If one brand doesn’t seem to produce the desired effect, you may want to try another.

CONCLUSION:We conclude that topical niacinamide is a safe and effective product for the treatment of age related skin changes (including wrinkling and discoloration). If you use it, remember to include it in your list of medications when you visit your doctor and other health care providers.

“Niacin/Niacinamide.” LLC, 2013. 21 September 2013
“Niacin.” Natural Standard –The Authority on Integrative Medicine. Natural Standard, 2013.
“Niacin and Niacinamide (Vitamin B3).” Natural Medicines Comprehensive Database. Therapeutic Research Faculty, 2013. 8 November 2013.

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