Red Wine and Resveratrol Supplement Review

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Red Wine and Resveratrol
  Evaluated for:
Effectiveness Rating Effectiveness Rating
Healthy aging (decreases gene changes associated with age-related frailty)
0 (Effectiveness Unclear)


  • Red wine, made from the juice of sun-ripened grapes, is associated with cardiovascular benefits when consumed in moderation.
  • Multiple animal studies have shown that resveratrol decreases progressive, age-related deterioration of the energy-producing mitochondria in cells. However, this finding has yet to be confirmed in humans.
  • In lab studies, resveratrol activated the same longevity genes that are known to be activated by calorie restriction.
  • Red wine may help lung function.
  • There are no significant side effects.


  • Red wine becomes problematic when imbibed in excess.
  • Red wine is a nervous system depressant.
  • The age-related benefits of resveratrol shown in animal studies have not yet shown the same results in humans. Future studies are needed to confirm the benefits.
  • Resveratrol is broken down by oxygen, so packaging would require nitrogen-infused single servings. Otherwise all the pills would begin to degrade the first time you opened a fresh bottle.
  • Side effects may include occasional flushing.

The recommended daily dose of 1000-1500 mg resveratrol would require you to drink more than 100 bottles of the very best red wine, which would create many more serious problems than it would solve.

DOSAGE:There is no standardized dose currently available for resveratrol. Limit red wine intake to 4 oz. per day in adult females and 8 oz. per day in adult males.

CONCLUSION:We conclude that while resveratrol shows promise for assisting in healthy aging, there is not enough evidence on humans for us to support its use for this indication. However, we do know that increasing the number of daily servings of fruits and vegetables is a reliable way to decrease the incidence of coronary artery disease, stroke, cancer, and other age-related diseases. Red grapes, red grapefruit, red wine, red watermelon and knotweed are good sources of resveratrol.

“Resveratrol.” LLC, 2013. 25 October 2013.
“Resveratrol.” Natural Standard –The Authority on Integrative Medicine. Natural Standard, 2013.
“Resveratrol.” Natural Medicines Comprehensive Database. Therapeutic Research Faculty, 2013. 8 November 2013.
Bailey, L. et al. Folate, Methyl-Related Nutrients, Alcohol, and the MTHFR 677C-T Polymorphism Affect Cancer Risk: Intake Recommendations. The Journal of Nutrition (2003) 133, 3748S-3753S
Resveratrol. EBSCO Publishing (2011) 1-3
Kennedy, D. et al. Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation. The American Journal of Clinical Nutrition (2010) 91:1590-7
Bertelli, A. et al. Grapes, Wines, Resveratrol, and Heart Health. J Cardiovasc Pharmacol (2009) 54:468-476
Khan, N. et al. Lifestyle as risk factor for cancer: Evidence from human studies. Cancer Letters (2010) 293:133-143
Calamini, B. et al. Pleiotropic mechanisms facilitated by resveratrol and its metabolites. Biochem J (2010) 429, 273-282
Brown, L. et al. The biological responses to resveratrol and other polyphenols from alcoholic beverages. Alcohol Clin Exp Res (2009) 33(9):1513-1523
Ungvari, Z. et al. Resveratrol confers endothelial protection viz activation of the antioxidant transcription factor Nrf2. Am J Physiol Heart Circ Physiol (2010) 288:H18-H24
Fischer-Posovszky, P. et al. Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner. The American Journal of Clinical Nutrition (2010) 92:5-15
Vang, O. et al. What Is New for an Old Molecule? Systematic Review and Recommendations on the Use of Resveratrol. PLoS ONE (2011) 6(6)
Opie, L., Lecour, S. et al. The red wine hypothesis: from concepts to protective signaling molecules. European Heart Journal (2007) 28, 1683-1693
Hamholz, S. et al. Wine, Spirits and the Lung: Good, Bad, or Indifferent?. Transactions of the American Clinical and Climatological Association (2006) 117, 129-145

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